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Veterinary Pharmacology & Toxicology

 

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About Department

When Haryana Agricultural University came into existence in February 1970, the Department of Pharmacology had a skeleton staff of two Assistant Professors in position. Subsequently it was in March 1971 when Prof. A. Ahmad joined as Professor and later in 1972 Dr. B. D. Garg joined as Associate Professor after completion of his Ph.D. from Ohio State University. Since then the department has been fast developing to achieve excellence. It would not be an exaggeration to mention that the level of teaching, research and expertise in the discipline attained in this department can be rated as second to none of the Dept. of Pharmacology among other Veterinary and Medical Institutions. The faculty consists of a team of well qualified and recognized personnel in different disciplines of the department.

The department has well established laboratories for teaching (UG & PG) and research particularly in the field of neuropharmacology, toxicology, pharmacokinetics and medicinal plants. The department has attracted a good number of meritorious graduates for post-graduate studies. Almost all of the students graduated from this department were research fellows of CSIR, ICAR and HAD. Since 1970, fifty five students have graduated for M.V.Sc. and Ph.D. degrees in Vety. Pharmacology/Vety. Pharmacology & Toxicology from this department.

Head of the Department :
 
 
Dr. Vinod Kumar
Phone (O): 01662-256120
(R): 01662-2245971
Mob.: +919467156560
Fax: +91 1662 284312
E-mail: hod.vpt@luvas.edu.in

 

 


Faculty

Dr. Vinod Kumar Head of the Department View Details
Dr. S. K. Jain Associate Professor View Details
Dr. Vinay Kant Assistant Professor View Details
Dr. Gaurav Gupta Assistant Professor View Details


Ministrial staff

Mrs. Chanchal Pruthi S.S.S.
Sh. Tej Pal Messenger

Laboratory staff
Sh.Jai Parkash Lab. Technician
Sh. Raj Pal Sr. Lab. Technician
Sh. Satyabhan Lab. Assistant
Smt. Rama Lab. Attendant

Other Supporting staff
Smt. Dulari Sweeper


Major Achievements

Autonomic Pharmacology
  • Characterized various adrenergic and purinergic receptors and their subtypes in different tissues of poultry; a difference from mammals was recorded.
  • Epinephrine rather than norepinephrine is the probable neurotransmitter in poultry.
  • The blood pressure of chicken is variable with age, sex and laying cycle - role of H1 and H2 receptors was elucidated.
  • In gastrointestinal tract, alpha receptors are both excitatory and inhibitory whereas beta receptors are inhibitory.
  • Possibility of third alpha receptor-subtype was revealed in infundibulum.
  • In Infundibulum excitatory alpha and beta receptors are present, alphaz receptors are present post synaptically.
  • Sex hormones affected the activity of both alpha, and alphaz receptor-subtypes.
  • In isthmus a new population of beta receptor-subtype was revealed.
  • An alternate model of isolated chicken duodenum for bioassay of cholinomimetic drugs was developed.
Pharmacokinetics of Chemotherapeutic Agents.
  • The dosage regimen of sulphonamides, antibiotics and other antimicrobials in health and diseased animals (buffaloes, goats, dogs and poultry) was established.
  • Sulphonamide - trimethoprim was found ideal for intrauterine infusion in uterine infection of buffaloes but was not rational for systemic administration.
  • For the control of susceptible bacterial diseases in poultry the dose of sulphadiazene (300 mg) + trimethroprim (60 mg) per litre water was found ideal.
  • Closantel and ivermectin were highly effective in Haemonchus contortus strain resistant to levamisol in goats and benzimidazole in sheep, thus preventing the losses in wool production and body weight gain.
Indigenous Medicinal/Toxic Plants :
  • Biological activities of several medicinal plants for their therapeutic values evaluated.
  • Marked antihypertensive activity comparable to reserpine was found in Anchusa strigosa (gaozban).
  • Aegle marmelos (Bael) .leaves possessed significant antidiabetic activity and potential to regenerate destroyed beta cells of Islets of Langerhans in pancreas.
  • Withania somnifera roots have protective effect on chlorpyrifos induced lipid peroxidation in brain liver and plasma of rats.
Toxicology of Xenobiotics :
  • Organophosphates on persistent low level exposure produced stress and lowering of resistance in animals.
  • The immunosuppressive effect of malathion to humoral immune response was through the cooperation of T cells in poultry.
  • Triazophos exhibited age and gender related differences on its neurotoxic effects in rats; young being more suspectible.
  • Plasma cholinesterase can be used as a reliable marker of triazophos toxicity in rats.


Post graduate students/ Research assistants/ Senior research fellows

  1. Preeti, Ph. D. Student
  2. Rajeev Sharma, Ph. D. Student
  3. Mohammed Shuaibu Auwal, Ph. D. Student
  4. Sunil Kumar, M.V.Sc. Student
  5. Aryan, M.V.Sc. Student
  6. Robin, M.V.Sc. Student


Research Projects

Ongoing projects
  1. Toxicological evaluation of newer pesticides: development of specific biomarker and antidotes
  2. Molecular and histological evaluation of wound healing potential of quercetin in diabetic rats
  3. Assessment of agrochemical residues in livestock, poultry and their products and its amelioration by herbal remedies
Completed projects
  1. Pharmacological Investigation of Medicinal Plants and Weeds
  2. Pharmacokinetic and Pharmacodynamic Studies on Drugs in /buffaloes
  3. Biological testing of extracts for their clinical efficacy


P.G. Thesis