Veterinary Pharmacology & Toxicology
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When Haryana Agricultural University came into existence in February 1970, the Department of Pharmacology had a skeleton staff of two Assistant Professors in position. Subsequently Prof. A. Ahmad joined as Professor in 1971 and Dr. B. D. Garg joined as Associate Professor in 1972. Since then the department has been fast developing to achieve excellence. It would not be an exaggeration to mention that the level of teaching, research and expertise in the discipline attained in this department can be rated as second to none of the Dept. of Pharmacology among other Veterinary and Medical Institutions. The faculty consists of a team of well qualified and recognized teachers and scientists.
The Department has organised two successful Annual Conferences of Indian Pharmacological Society in 1973 and 1993. Apart from this, one Annual Conference of Indian Pharmacological Society (North zone) was conducted in 1988. Two successful summer institutes were also organised by the department in 1974 and 1987. A UGC sponsored Symposium on "Living in Pesticide- Polluted Environment" was organised in 1977. The department has organized 17th Annual Conference of Indian Society of Veterinary Pharmacology and Toxicology and National Symposium on “Combating Antimicrobial Resistance” from 20-22 December, 2017.
The department has well established laboratories for teaching (Undergraduate & Postgraduate) and research particularly in the field of neuropharmacology, molecular pharmacology, toxicology, pharmacokinetics and ethnopharmacology. The department has attracted a good number of meritorious graduates for post-graduate studies. Many of the students graduated from this department were research fellows of CSIR, ICAR etc. Since 1970, fifty four students have graduated with M.V.Sc. and twenty seven with Ph.D. degrees in Vety. Pharmacology/Vety. Pharmacology & Toxicology from this department.Head of the Department :
Dr. Vinod Kumar
Phone (O): 01662-256120
Fax: +91 1662 284312
|Sh. Vivek Chopra
|Sh. Heera Lal
||Sr. Lab. Assistant
|Sh. Balbir Jhorad
Other Supporting staff
Pharmacokinetics of Chemotherapeutic Agents.
- Characterized various adrenergic and purinergic receptors and their subtypes in different tissues of poultry; a difference from mammals was recorded.
- Epinephrine rather than norepinephrine is the probable neurotransmitter in poultry.
- The blood pressure of chicken is variable with age, sex and laying cycle - role of H1 and H2 receptors was elucidated.
- In gastrointestinal tract, alpha receptors are both excitatory and inhibitory whereas beta receptors are inhibitory.
- Possibility of third alpha receptor-subtype was revealed in infundibulum.
- In Infundibulum excitatory alpha and beta receptors are present, alpha-z receptors are present post synaptically.
- Sex hormones affected the activity of both alpha-1 and alpha-z receptor-subtypes.
- In isthmus a new population of beta receptor-subtype was revealed.
- An alternate model of isolated chicken duodenum for bioassay of cholinomimetic drugs was developed.
Indigenous Medicinal/Toxic Plants :
- The dosage regimen of sulphonamides, antibiotics and other antimicrobials in health and diseased animals (buffaloes, goats, dogs and poultry) was established.
- Sulphonamide - trimethoprim was found ideal for intrauterine infusion in uterine infection of buffaloes but was not rational for systemic administration.
- For the control of susceptible bacterial diseases in poultry the dose of sulphadiazene (300 mg) + trimethroprim (60 mg) per litre water was found ideal.
- Closantel and ivermectin were highly effective in Haemonchus contortus strain resistant to levamisol in goats and benzimidazole in sheep, thus preventing the losses in wool production and body weight gain.
Toxicology of Xenobiotics :
- Biological activities of several medicinal plants for their therapeutic values evaluated.
- Marked antihypertensive activity comparable to reserpine was found in Anchusa strigosa (gaozban).
- Aegle marmelos (Bael) .leaves possessed significant antidiabetic activity and potential to regenerate destroyed beta cells of Islets of Langerhans in pancreas.
- Withania somnifera roots have protective effect on chlorpyrifos induced lipid peroxidation in brain liver and plasma of rats.
- Organophosphates on persistent low level exposure produced stress and lowering of resistance in animals.
- The immunosuppressive effect of malathion to humoral immune response was through the cooperation of T cells in poultry.
- Triazophos exhibited age and gender related differences on its neurotoxic effects in rats; young being more suspectible.
- Plasma cholinesterase can be used as a reliable marker of triazophos toxicity in rats.
Post graduate students/ Research assistants/ Senior research fellows
- Preeti Singh, Ph. D. Student
- Sonu Devi, PhD. Student
- Kamothi Dhaval Jitendra, M.V.Sc. Student
- Santosh Dharam Dev Yadav, M.V.Sc. Student
- Siddharth Thakur, MVSc. Student
- Preetam, MVSc. Student
- Sandeep Singh, MVSc. Student
- Pharmacological and toxicological studies of newer drugs, herbals and agrochemicals in animals and poultry
- Investigation of analgesic and anti-inflammatory activities in polyherbal formulation prepared from Mangifera indica, Azadirachta indica, Ocimum sanctum and Psidium guajava
- Pharmacological Investigation of Medicinal Plants and Weeds
- Pharmacokinetic and Pharmacodynamic Studies on Drugs in /buffaloes
- Biological testing of extracts for their clinical efficacy
- Molecular and histological evaluation of wound healing potential of quercetin in diabetic rats
- Assessment of agrochemical residues in livestock, poultry and their products and its amelioration by herbal remedies
- Toxicological evaluation of newer pesticides: development of specific biomarker and antidotes
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